Folate Therapy after Coronary Stenting
Some studies have shown that the use of folate supplementation
to lower plasma homocysteine levels reduces the rate of
restenosis in patients who have undergone angioplasty,
but results have been inconsistent. In this study, patients
who had received a coronary stent were randomly assigned
to receive placebo or a combination of folate, vitamin
B6, and vitamin B12. Those receiving active therapy had
a higher rate of in-stent restenosis. Folate therapy cannot
be routinely recommended after coronary stenting.
N Engl J Med, 2004; 350 : 2673.