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JG Saluja*, Amit Ranadive**, MS Ajinkya***, Leroy Rebello****
 

Abstract

Vaginal Leiomyoma is a rare tumour with a variable presentation. Vaginal Leiomyoma can also present as a imitator of prolapse. Shaw reported a case of Leiomyoma that became clinically apparent at postpartum period. A surgical approach through the anterior vaginal wall avoids urethral injury; an enucleation is curative.

Introduction

Leiomyoma is the benign mesenchymal tumour of the vagina. The patients are adults and any region of the vagina can be affected.1,2 The utility of sonography in the evaluation of the internal anatomy of the female pelvis is well established, but little has been reported on the characterization of vaginal masses. Prolapsing fibromyomas can be diagnosed via the contiguous uterine component. The tumours are often rare and asymptomatic but can cause dyspareunia, urinary urgency and urge incontinence.3,4

Case Report

We present a case of vaginal Leiomyoma of a woman age 32 years married with swelling on the left vaginal wall since 1-2 years complaining of dull aching pain. Clinical examination reveal hard nodular peanut size swelling, movable measuring 3 x 2 x 2 cms arising from anterior vaginal wall. Pathologically tumour mass was well circumscribed and had the typical microscopic feature of benign Leiomyoma as found elsewhere.

Discussion

Vaginal Leiomyoma is a rare tumour with a variable clinical presentation and broad differential diagnosis that can lead to pre- operative misdiagnosis. Leiomyoma developing de novo from elements of vagina is a rare phenomenon.5,6 Tumours arising from the upper part of vagina is mistaken for a cervical fibroid. Vaginal Leiomyoma can also present as a imitator of prolapse. Leiomyosarcoma and Leiomyoma of the vagina has been reported where the treatment of choice is chemotherapy and enucleation of Leiomyoma because of the possibility of undergoing malignant change.7

leiomyoma
Fig. 1 : H and E stained section 10x - leiomyoma.

The solid tumours arising from vagina include papilloma haemangioma rarely Leiomyoma since the vaginal mucosa is a non keratinizing squamous epithelium. There is numerous lymphatics and venous pleuxis. The submucosa is surrounded by tunica muscularis vaginae, overlaid by longitudinal layer of loose connective tissue cover in turn. Shaw reported a case of Leiomyoma that became clinically apparent at postpartum period.8-10 Correct pre-operative diagnosis of these lesions can avert the therapeutic error. Diagnostic clues include a solid noncystic mass that does not communicate with the urethra, is circumscribed and has essentially normal overlying mucosa. A surgical approach through the anterior vaginal wall avoids urethral injury and enucleation is curative.11

Finally one should consider and advice for ultrasonography, MRI, positive pressure urethrography and urethrocystoscopy in the evaluation of an anterior wall vaginal mass. If surgical procedure results in skeletanization of the urethral and bladder support, a colporrhaphy/pubourethral ligament plication is advised.4

References

  1. Ramackers F, Tondan A, et al. P53 and human papilloma virus type 16 cervical intraepithelial neoplasia and carcinoma. Int J Gynaecol Pathol 1994; 14 : 125-33.
  2. A Kasofu M, Oda Y. Immunohistochemical detection of P53 in cervical epithelial lesion with or without infection of human papilloma virus type 16 and 18 Virchow’s Arch 1995; 425 :
    593-602.
  3. McCarthy S, Taylor KJ. Sonography of Vaginal masses. A JR Am J Roentgenol 1993; 140 (5) : 1005-8.
  4. Leron E, Stanton SL. Vaginal Leiomyoma - an imitator of prolapse. Int Urogynaecol J Pelvic Floor Dysfunct 2000; 11 (3) : 196-8.
  5. Hazra PC, Singhal S, et al. Leiomyoma of Vagina. J Indian Med Ass 1998; 60-61.
  6. Castle WN, Mc Laughlim WL. Paraurethral Leiomyoma. 1987; 30 : 70-72.
  7. Hom LC, Fischer U, et al. Leiomyosarcoma and Leiomyoma of the vagina. Zentralbi Gynakal Institat fur pathologie, Universitat Leipzig. 1998; 120 (1) : 38-41.
  8. Young SB, Rose PG, et al. V Fibromyomata. Two cases with pre-operative assessment, resection reconstruction. Obstet Gynaecol 1991; 78 :
    972-74.
  9. Tobon H Murphy, et al. Leiomyosarcoma of the vagina. Light and electron microscopic observations. Cancer 1973; 32 : 450-57.
  10. Shaw CT. Vaginal Leiomyoma as a cause of pelvic pain and cystitis cystica. J Am Osteopath Assoc 1989; 89 : 1330-31.
  11. Cattolica EV, Klein R, et al. Paraurethral leiomyoma - an imitator. Urology 1976; 8 (6) : 605-7.

MYOCARDIAL INFARCTION AND DIABETES RISK

`Patient with a recent myocardial infarction had a higher annual incidence rate of impaired fasting glucose [....] and diabetes [...]. Myocardial infarction could be a prediabetes risk equivalent'

People with diabetes are at higher risk of myocardial infarction than non-diabetics. Dariush Mozaffarian and colleagues did a prospective study to investigate the converse: whether people who have had a myocardial infarction are at higher risk of developing diabetes. They showed that a third of patients (2514/7533) developed new diabetes or impaired fasting glucose (³ 6.1 mmol/L) within a mean follow-up of 3.2 years. They also showed that patients who stopped smoking, did not gain weight, and consumed typical Mediterranean foods had a lower risk, and suggest that advice on such lifestyle factors be incorporated into counselling for patients who have had a myocardial infarction. In a linked Comment, Lionel Opie discusses factors that might mediate this shared risk, including use of diuretics, b blockers, and diet.

Lancet Infect Dis, 2007; 7 : 634, 667.

*Associate Professor, **Resident, Department of Ophthalmology, T.N.M.C and B.Y.L. Nair Hospital, Mumbai - 400 008.

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